Published : 16 Sep 2016, 02:50 AM
Europe's second-tier contest began in earnest with three-time continental champions United topping the bill in Group A, but Jose Mourinho's side were undone after a poor display in which clearcut chances were at a premium.
It was a different story in Israel where there were goals galore in Maccabi Tel Aviv's game against Zenit St Petersburg with the Russian club fighting back from 3-0 down to win 4-3 with all their goals coming from the 77th minute onwards.

For United it was a second defeat in six days after they lost to rivals Manchester City in the Premier League, and it ended Mourinho's honeymoon period after he began the season with four straight wins including a Community Shield victory.
United never really looked like scoring even after striker Zlatan Ibrahimovic was introduced in the second half as part of a triple substitution and they were picked off on the counter in the 79th minute.
Nicolai Jorgensen looked offside when he burst clear on the right flank but he crossed low for Trindade to slide the ball past David De Gea with a precise sidefooted finish.

Zenit looked beaten when they fell 3-0 behind in the 70th minute against Maccabi but Aleksandr Kokorin headed home to begin the comeback before Eli Dasa was sent off for the Israelis in the 81st.
Further Zenit goals soon after from Brazilians Mauricio and Giuliano drew the Russians level and Luka Djordjevic remarkably grabbed the winner two minutes into stoppage time.
Roma, who have made a bright start in Serie A with seven points from their opening three games, took the lead against Plzen in Group E from the penalty spot when Diego Perotti calmly stroked home after Stephan El Shaarawy was felled.
The lead lasted just seven minutes, however, as Martin Zeman's whipped cross found Marek Bakos to head the hosts level.

After a goalless first half, the Italians took the lead on the hour mark when Pol Lirola skipped past one challenge and bent the ball home. They doubled their advantage 15 minutes later when Gregoire Defrel raced clear to finish calmly.
Sassuolo rounded off a stunning performance with Matteo Politano's clinical finish in the 82nd minute.