Dhaka Metropolitan Police said they seized 6,500 yaba pills, 10kg marijuana, heroin and bottles of phensedyl during the drive on Number 14 Outfall City slum at Dhalpur on Monday.
Detectives also worked with them.
Iftekhayerul said most of the slum dwellers were cleaners and staffers of Dhaka South City Corporation. The law enforcers cordoned off the area and searched every shanty.
Police said the arrested people included drug peddlers, suppliers and addicts.
At least 91 people have been killed in alleged shootouts since law enforcers began an anti-drug campaign on May 19 after Prime Minister Sheikh Hasina declared a war on drugs.
Hundreds of people have been arrested in raids across the country, including the capital.
Home Minister Asaduzzaman Khan Kamal said security forces were conducting an ‘all-out war’ on drugs and will continue to do so until trafficking was eliminated.