Rizwan and Irfan both suffered hamstring injuries in the third match in Rawalpindi, where a second-string New Zealand side won by seven wickets to level the five-match series 1-1
Samuels (76) and Bravo (87) batted resolutely before an aggressive spell of bowling from Wahab Riaz allowed Pakistan, who declared their first innings at 579 for three wickets, to make inroads into the visitors' middle order.
Wahab took the wickets of Jermaine Blackwood (37) and Roston Chase (6) before West Indies, 69-1 overnight, finished the day on 315-6.
Mohammad Nawaz took his maiden Test wicket when he had Bravo caught by Azhar Ali, who had returned to take up position at short leg after going off for treatment when he took a blow to his right hand.