Washington’s major European allies opposed US President Donald Trump’s decision to abandon the deal and have been trying to salvage the pact.
“America’s enmity toward Iran is obvious. Our enemies’ heart is full of enmity toward the Islamic Republic ... our officials should not be deceived by the Europeans ... don’t be fooled by Europeans,” Khamenei said, state TV reported.
Iran has called on the EU to do more to show its commitment to the deal, despite a new European mechanism for non-dollar trade with Iran to avoid US sanctions.
Under the deal, all international sanctions on Iran were lifted in 2016 in return for Tehran accepting curbs on its nuclear program.
Washington reimposed sanctions on Iran last year, targeting its oil and banking sectors.