PSG are on 69 points with four games left with Monaco trailing by 11 points
The twice World Cup winners and current Copa America champions have qualified for the finals in Qatar and sit second in the 10-team South American group.
The 34-year-old Messi was omitted from Argentina’s 27-man squad after not playing for PSG since Dec 22 against FC Lorient in French Ligue 1.
Messi spent the festive period in Argentina before testing positive for COVID-19 and trained separately from his team mates on his return to Paris.
PSG face Real Madrid in the last 16 of the Champions League with the first leg on Feb 15.
Argentina are away to Chile on Jan 27 and host Colombia on Feb 1.