Gaga, the "Born This Way" singer best known for her flamboyant stunts on stage, plays an aspiring singer in the third remake of the romance between an aging star and a newcomer.
"I have always wanted to be an actress and this is more than I ever imagined," she told reporters on the red carpet at the Toronto Film Festival on Sunday. "I am just so honoured and grateful and humbled."
Gaga insisted that all the songs in "A Star is Born" were performed live, including those by her co-star Bradley Cooper, a novice musician.
"Singing live, there really was no question," Cooper, who also directed the film, told a news conference earlier on Sunday.
"When we first met, Stefani was very adamant about it," said Cooper, referring to Lady Gaga by her real name, Stefani Germanotta.
"A Star is Born" tells the story of country music singer Jackson Maine (Cooper), who meets, nurtures and falls in love with aspiring musician Ally (Lady Gaga). As Jackson deals with addiction and tinnitus and his own star wanes, Ally's career takes off.
"Preparation was the hardest thing," he said. "Starting to sing and realising that I really couldn't; starting to learn guitar and piano and realising I couldn't."
Gaga made her television acting debut in "American Horror Story: Hotel" winning a Golden Globe in 2016. But taking the lead role in "A Star is Born" was a big leap.
"At the beginning of making this film, we shook hands literally, and he said to me, 'You are an actress'," Gaga said. "And I said to him, 'You are a musician'."
The movie's concert scenes were shot on the stages of some of the world's biggest music festivals, including Coachella in California and Glastonbury in England.
"A Star is Born" is the third remake of the original 1937 film. It was remade in 1954 with Judy Garland, and in 1976 with Barbra Streisand.