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An unidentified 33-year-old man was killed in the shooting at the Irving Plaza in Manhattan shortly before Grammy-Award winning rapper TI took the stage, the New York Times said.
Three unidentified people were also wounded in the shooting, New York city police said, adding that they had not yet made any arrests.
A video clip posted on Twitter showed dozens of screaming people rushing away from the stage and falling to the ground as shots rang out.
A CBS affiliate in New York city reported three men and one woman were shot in the incident, which police said took place on the third floor of the 1,025-person venue.
In 2015, two people were wounded in a shooting at a North Carolina nightclub featuring the same performer.