Drake took home his first AMA trophies for Favourite Artist Rap/Hip-Hop, Favourite Album Rap/Hip-Hop and Favourite Song Rap/Hip-Hop.
‘Work’, his collaboration with Rihanna also won for Favourite Song Soul/R&B.
Bieber scored the Video of the Year for the hit "Sorry", Favourite Male Artist Pop/Rock and Favourite Album Pop/Rock.
The Artist of the Year award was won by Ariana Grande while former One Direction band member Zayn Malik was announced as the New Artist of the Year Un-leashed by T-Mobile.
Collaboration of the Year award was given to Fifth Harmony featuring Ty Dolla $ign for "Work from Home".
Tour of the Year went to Beyoncé, who beat Madonna, Bruce Springsteen & the E Street Band for the honour.
After competing with nominees Adele and Rihanna, Selena Gomez took home the Favourite Female Artist Pop/Rock award.
Rihanna won the Favourite Female Artist Soul/R&B award.
The Favourite Male Artist Soul/R&B award was won by Chris Brown.
The Chainsmokers took home the Favourite Artist Electronic Dance Music (EDM) award edging out acts like Calvin Harris and Major Lazer.