The voting will start at 8 in the morning and continue until 4pm without any break on Thursday.
The BNP, which was critical about the last EC, hopes that the Huda-led EC will reflect public expectations.
Polls officials and law-enforcing agencies have said the entire city has been covered under a security blanket to facilitate a peaceful election.
Huda, who is under BNP scrutiny since assuming office, has finally 'own' their confidence ahead of Comilla election when the BNP leader praised him as a 'nobleman'.
Initially, the BNP called him 'subservient' to the ruling Awami League.
"The Comilla City election is an acid test to the current EC. Many political parties have many questions to this EC. If it passes this test, it will gain the political parties' confidence," said BNP leader Ruhul Kabir Rizvi.
The EC has 'presented some proof' of its effort to keep the Comilla civic polls free and fair by transferring 19 police personnel from Comilla Sadar South area to other places of the city on the day before the polls following an allegation.
"We have taken steps following allegations brought by the two major parties to ensure maximum security," said EC Secretary Mohammad Abdullah.
"We will use whatever tool is necessary to prevent disorder," he added.
Comilla Superintendent of Police Shah Abid Hossain said at the briefing, "We will show 'zero tolerance' to any sort of irregularity, violence and disorder."
"No one will be able to flee unharmed after violence at polling stations," he added.
Nine judicial and 27 executive magistrates will round the polls areas.
The voting will be held at 103 centres from 8am to 4pm. The number of voters is a little over 200,000.
Ruling Awami League's mayoral candidate Anjum Sultana Sima with 'boat' symbol spent the eve of the vote by exchanging views with leaders and activists at her home in Thakurparha.
Her father Afzal Khan lost to BNP leader Monirul Haque Shakku in the first polls to Comilla City Corporation in 2012.
Shakku is fighting the polls, which are being held on party lines for the first time, with the BNP's electoral symbol 'paddy sheaf'.
He also spent the day before the vote by exchanging views with his supporter at his home in Bajrapur.
The number of candidates vying for 27 ward councillor posts and nine councillor posts reserved for women is 154.
A voter can get the name of his or her polling station, voter number and serial number by sending a SMS writing: 'PC<Space>17-digit NID number' to 105.
Those with 13-digit NID number will have to add the birth year before the number.
Returning Officer Rakib, however, said the matter would not affect the polls because the 'militant den' is 'far away' from the nearest polling station.
CEC Huda urged the voters not to panic due to the drive. Police said they would not launch an operation to neutralise the suspects before the end of voting.