The raid was conducted in Moijjartek area around 3am on Thursday, said Mukul Jyoti Chakma, deputy director of DNC Chittagong Metropolitan Sub-Zone.
The detained driver, Nurul Islam, 32, was coming to Chittagong from Teknaf.
The Yabas were kept in 30 bags, Chakma said.
A case was being filed with the Karnaphuil Police, the DNC official said.